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Article

A cellular model reflecting the phenotypic heterogeneity of mutant HRAS driven squamous cell carcinoma.

International journal of cancer - 1 Sept 2016

Cantariño Neus, Fernández-Figueras M Teresa, Valero Vanesa, Musulén Eva, Malinverni Roberto, Granada Isabel, Goldie Stephen J, Martín-Caballero Juan, Douet Julien, Forcales Sonia-Vanina, Buschbeck Marcus

Abstract excerpt

Squamous cell carcinomas have a range of histopathological manifestations. The parameters that determine this clinically observed heterogeneity are not fully understood. Here, we report the generation of a cell culture model that reflects part of this heterogeneity. We have used the catalytic subunit of human telomerase hTERT and large T to immortalize primary UV-unexposed keratinocytes. Then, mutant HRAS G12V...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27074337
DOI: 10.1002/ijc.30139

Genes

HRAS
PADI2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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