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Article

Mesenchymal Cell Reprogramming in Experimental MPLW515L Mouse Model of Myelofibrosis.

PloS one - 1 Jan 2017

Han Ying, Yue Lanzhu, Wei Max, Ren Xiubao, Shao Zonghong, Zhang Ling, Levine Ross L, Epling-Burnette Pearlie K

Abstract excerpt

Myelofibrosis is an indicator of poor prognosis in myeloproliferative neoplasms (MPNs), but the precise mechanism(s) contributing to extracellular matrix remodeling and collagen deposition in the bone marrow (BM) niche remains unanswered. In this study, we isolated mesenchymal stromal cells (MSCs) from mice transplanted with wild-type thrombopoietin receptor (MPLWT) and MPLW515L retroviral-transduced bone marrow....

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Identifiers

PMID: 28135282
DOI: 10.1371/journal.pone.0166014
PMCID: PMC5279751

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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