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Article

TGF-β1 protein trap AVID200 beneficially affects hematopoiesis and bone marrow fibrosis in myelofibrosis.

JCI insight - 22 Sept 2021

Varricchio Lilian, Iancu-Rubin Camelia, Upadhyaya Bhaskar, Zingariello Maria, Martelli Fabrizio, Verachi Paola, Clementelli Cara, Denis Jean-Francois, Rahman Adeeb H, Tremblay Gilles, Mascarenhas John, Mesa Ruben A, O'Connor-McCourt Maureen, Migliaccio Anna Rita, Hoffman Ronald

Abstract excerpt

Myelofibrosis (MF) is a progressive chronic myeloproliferative neoplasm characterized by hyperactivation of JAK/STAT signaling and dysregulation of the transcription factor GATA1 in megakaryocytes (MKs). TGF-β plays a pivotal role in the pathobiology of MF by promoting BM fibrosis and collagen deposition and by enhancing the dormancy of normal hematopoietic stem cells (HSCs). In this study, we show that MF-MKs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 34383713
DOI: 10.1172/jci.insight.145651
PMCID: PMC8492354

Genes

SMAD2
GATA1
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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