Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bone morphogenetic proteins are overexpressed in the bone marrow of primary myelofibrosis and are apparently induced by fibrogenic cytokines.

The American journal of pathology - 1 Apr 2008

Bock Oliver, Höftmann Julia, Theophile Katharina, Hussein Kais, Wiese Birgitt, Schlué Jerome, Kreipe Hans

Abstract excerpt

Primary myelofibrosis (PMF) is a myeloproliferative neoplasia characterized by progressive deposition of extracellular matrix components in the bone marrow. The involvement of members of the bone morphogenetic protein (BMP) family in aberrant bone marrow matrix homeostasis in PMF has not yet been investigated. Therefore, we analyzed expression of BMP1, an activator of latent transforming growth factor beta-1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Protein Receptors, Type II
Share to Bone Morphogenetic Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblast Growth Factor 2

Share to Megakaryocytes

Share to Primary Myelofibrosis

Share to Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase

Share to Stromal Cells

Share to Transforming Growth Factor beta1

Source

Open in PubMed Open full text

Identifiers

PMID: 18349123
DOI: 10.2353/ajpath.2008.071030
PMCID: PMC2276425

Genes

BMP1
BMP6
BMP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bone morphogenetic proteins are overexpressed in the bone marrow of primary myelofibrosis and are apparently induced by fibrogenic cytokines.PMID 18349123Read ↗

The role of the extracellular matrix in primary myelofibrosis.Semantic proximity Read ↗

Neoplastic fibrocytes play an essential role in bone marrow fibrosis in Jak2V617F-induced primary myelofibrosis mice.Semantic proximity Read ↗

Profile of fibrosis-related gene transcripts and megakaryocytic changes in the bone marrow of myelodysplastic syndromes with fibrosis.Semantic proximity Read ↗

Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN.Semantic proximity Read ↗

Pathogenesis of myelofibrosis with myeloid metaplasia.Semantic proximity Read ↗

Mesenchymal Cell Reprogramming in Experimental MPLW515L Mouse Model of Myelofibrosis.Semantic proximity Read ↗

Inhibition of the EBF1-ITGB8 Axis in Bone Marrow Niche Ameliorates Hallmarks of MyelofibrosisSemantic proximity Read ↗

Increased megakaryocytic proliferation, pro-platelet deposition and expression of fibrosis-associated factors in children with chronic myeloid leukaemia with bone marrow fibrosis.Semantic proximity Read ↗

[Cytokines in bone diseases. BMP signaling and fibrodysplasia ossificans progressiva].Semantic proximity Read ↗

Preclinical rationale for TGF-β inhibition as a therapeutic target for the treatment of myelofibrosis.Semantic proximity Read ↗

Bone marrow fibrosis with fibrocytic and immunoregulatory responses induced by β-catenin activation in osteoprogenitors.Semantic proximity Read ↗

TGF-β1 protein trap AVID200 beneficially affects hematopoiesis and bone marrow fibrosis in myelofibrosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.