Article
Clinical genetics of hereditary colorectal cancer.
Hematology/oncology clinics of North America - 1 Oct 2010
Power Derek G, Gloglowski Emily, Lipkin Steven M
Abstract excerpt
Colorectal cancer (CRC) is a common disease, and approximately 25% of patients have a familial component. High-penetrance singlegene germline mutations conferring a true hereditary susceptibility account for around 5% to 6% of all cases. Lynch syndrome is the most common hereditary form of colorectal cancer. Much of the hereditary component in the remaining familial cases of CRC is likely polygenic, and many of...
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