Article
A paradigm shift in genetic predisposition to colorectal cancer: the impact of germline multigene panel testing on diagnosis and management.
International journal of clinical oncology - 1 May 2026
Fujiyoshi Kenji, Sudo Tomoya, Shimamura Satoshi, Sugihara Rie, Hisada Kahori, Takaki Kenta, Takamatsu Masayuki, Kikuchi Maako, Koga Fumiki, Shigaki Takahiro, Yoshida Naohiro, Ohchi Takafumi, Goto Yuichi, Yoshida Takefumi, Isobe Taro, Mori Naoki, Sakai Hisamune, Hisaka Toru, Fujita Fumihiko
Abstract excerpt
Hereditary colorectal cancer (HCRC), arising from pathogenic germline variants, accounts for 5-10% of all CRCs. The widespread clinical adoption of next-generation sequencing (NGS) and multigene panel testing (MGPT) has fundamentally transformed the diagnostic paradigm for this genetic predisposition. This review summarizes the latest epidemiological data on genetic predisposition to CRC and examines the...
Topics
- Humans
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Colorectal Neoplasms
- Genetic Testing
- Precision Medicine
- High-Throughput Nucleotide Sequencing
- Colorectal Neoplasms, Hereditary Nonpolyposis