Article
Influence of common polymorphisms in the SLC5A2 gene on metabolic traits in subjects at increased risk of diabetes and on response to empagliflozin treatment in patients with diabetes.
Pharmacogenetics and genomics - 1 Apr 2017
Zimdahl Heike, Haupt Axel, Brendel Michael, Bour Louis, Machicao Fausto, Salsali Afshin, Broedl Uli C, Woerle Hans-Juergen, Häring Hans-Ulrich, Staiger Harald
Abstract excerpt
OBJECTIVE: Inhibition of the renal sodium-glucose cotransporter 2 (SGLT2) is a novel concept in the therapy of diabetes mellitus. In this study, we first assessed whether common single nucleotide polymorphisms (SNPs) in the SGLT2-encoding gene SLC5A2 affect diabetes-related metabolic traits in subjects at risk for type 2 diabetes and, second, whether these have pharmacogenetic relevance by interfering with the...
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