Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Search for a Functional Genetic Variant Mimicking the Effect of SGLT2 Inhibitor Treatment.

Genes - 29 Jul 2021

Wang Siqi, Said M Abdullah, Groot Hilde E, van der Most Peter J, Thio Chris H L, van de Vegte Yordi J, Verweij Niek, Snieder Harold, van der Harst Pim

Abstract excerpt

SGLT2 inhibitors (SGLT2i) block renal glucose reabsorption. Due to the unexpected beneficial observations in type 2 diabetic patients potentially related to increased natriuresis, SGLT2i are also studied for heart failure treatment. This study aimed to identify genetic variants mimicking SGLT2i to further our understanding of the potential underlying biological mechanisms. Using the UK Biobank resource, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Variation
Share to Glycated Hemoglobin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 34440348
DOI: 10.3390/genes12081174
PMCID: PMC8391850

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Search for a Functional Genetic Variant Mimicking the Effect of SGLT2 Inhibitor Treatment.PMID 34440348Read ↗

Genetic variation in solute carrier family 5 member 2 mimicking sodium-glucose co-transporter 2-inhibition and risk of cardiovascular disease and all-cause mortality: reduced risk not explained by lower plasma glucose.Semantic proximity Read ↗

Genetic Variation in Sodium-glucose Cotransporter 2 and Heart Failure.Semantic proximity Read ↗

Treatment Response to SGLT2 Inhibitors: From Clinical Characteristics to Genetic VariationsSemantic proximity Read ↗

Role of genetic variation in the human sodium-glucose cotransporter 2 gene (SGLT2) in glucose homeostasis.Semantic proximity Read ↗

Sodium-glucose cotransporter 1 inhibition and gout: Mendelian randomisation study.Semantic proximity Read ↗

A novel SGLT2 mutation in a patient with autosomal recessive renal glucosuria.Semantic proximity Read ↗

Renal glucosuria due to SGLT2 mutationsSemantic proximity Read ↗

A novel sodium-glucose co-transporter 2 gene (SGLT2) mutation contributes to the abnormal expression of SGLT2 in renal tissues in familial renal glucosuria.Semantic proximity Read ↗

Mendelian randomization study of sodium-glucose cotransporter 2 inhibitors in cardiac and renal diseases.Semantic proximity Read ↗

Molecular analysis of the SGLT2 gene in patients with renal glucosuria.Semantic proximity Read ↗

Abnormal expression and dysfunction of novel SGLT2 mutations identified in familial renal glucosuria patients.Semantic proximity Read ↗

Influence of common polymorphisms in the SLC5A2 gene on metabolic traits in subjects at increased risk of diabetes and on response to empagliflozin treatment in patients with diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.