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Article

Role of genetic variation in the human sodium-glucose cotransporter 2 gene (SGLT2) in glucose homeostasis.

Pharmacogenomics - 1 Aug 2011

Enigk Uta, Breitfeld Jana, Schleinitz Dorit, Dietrich Kerstin, Halbritter Jan, Fischer-Rosinsky Antje, Enigk Beate, Müller Ines, Spranger Joachim, Pfeiffer Andreas, Stumvoll Michael, Kovacs Peter, Tönjes Anke

Abstract excerpt

AIMS: Mutations in the sodium-glucose cotransporter 2 (SGLT2), as well as treatment with SGLT2 inhibitors result in reduced fasting glucose levels, HbA(1c) and BMI. We therefore investigated the effects of common genetic variation in SGLT2 on human Type 2 diabetes and related traits. MATERIALS & METHODS: Four HapMap tagging SNPs covering the common genetic variation in SGLT2 (r² > 0.8 and minor allele frequency >...

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PMID: 21830867
DOI: 10.2217/pgs.11.69

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