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Article

Common variation in the sodium/glucose cotransporter 2 gene SLC5A2 does neither affect fasting nor glucose-suppressed plasma glucagon concentrations.

PloS one - 1 Jan 2017

Ordelheide Anna-Maria, Böhm Anja, Kempe-Teufel Daniela, Wagner Robert, Machicao Fausto, Heni Martin, Stefan Norbert, Fritsche Andreas, Häring Hans-Ulrich, Staiger Harald

Abstract excerpt

AIM: Inhibition of sodium/glucose cotransporter 2 (SGLT2), the key transport protein in renal glucose reabsorption, promotes glucose excretion and represents a new concept in the therapy of type-2 diabetes. In addition, SGLT2 inhibition elevates circulating glucagon concentrations and enhances hepatic glucose production. Since SGLT2 is expressed in human pancreatic α-cells and regulates glucagon release, we...

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Source

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Identifiers

PMID: 28472182
DOI: 10.1371/journal.pone.0177148
PMCID: PMC5417681

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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