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Article

GLP1R and OCT1 variants modulate semaglutide and metformin response in type 2 diabetes.

Pharmacogenetics and genomics - 1 Jan 2026

Tourtourikov Ivan, Kalinkova Maria, Ivanov Peter, Mileva-Popova Rene, Tafradjiiska-Hadjiolova Radka, Handjieva-Darlenska Teodora, Kadiyska Tanya

Abstract excerpt

BACKGROUND: Large consortia link variants in SLC22A1 , SLC47A1 , and GLP1R to antidiabetic response, yet few data confirm these effects in small real-world cohorts. We tested whether three common polymorphisms translate into measurable 3-month metabolic changes. METHODS: Twenty-seven Bulgarian adults with type 2 diabetes [BMI ≥ 25 kg/m²; mean glycated hemoglobin (HbA1c): 8.3 ± 0.9%] received metformin XR 2000 mg...

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Share to Diabetes Mellitus, Type 2
Share to Glucagon-Like Peptide 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucagon-Like Peptide-1 Receptor

Share to Glycated Hemoglobin

Share to Hypoglycemic Agents

Share to Metformin

Share to Octamer Transcription Factor-1

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Source

Identifiers

PMID: 40996853
DOI: 10.1097/FPC.0000000000000577

Genes

GLP1R
SLC22A1
SLC47A1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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