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Article

A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell.

American journal of human genetics - 6 Feb 2014

Kulzer Jennifer R, Stitzel Michael L, Morken Mario A, Huyghe Jeroen R, Fuchsberger Christian, Kuusisto Johanna, Laakso Markku, Boehnke Michael, Collins Francis S, Mohlke Karen L

Abstract excerpt

Genome-wide association studies (GWASs) have identified more than 70 loci associated with type 2 diabetes (T2D), but for most, the underlying causal variants, associated genes, and functional mechanisms remain unknown. At a T2D- and fasting-proinsulin-associated locus on 11q13.4, we have identified a functional regulatory DNA variant, a candidate target gene, and a plausible underlying molecular mechanism. Fine...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Homeodomain Proteins

Share to Insulin-Secreting Cells

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Source

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Identifiers

PMID: 24439111
DOI: 10.1016/j.ajhg.2013.12.011
PMCID: PMC3928648

Genes

PAX4
PAX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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