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Article

Roles for the CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine Systems in Hypoxic Pulmonary Hypertension.

American journal of respiratory cell and molecular biology - 1 May 2017

Amsellem Valérie, Abid Shariq, Poupel Lucie, Parpaleix Aurélien, Rodero Mathieu, Gary-Bobo Guillaume, Latiri Mehdi, Dubois-Rande Jean-Luc, Lipskaia Larissa, Combadiere Christophe, Adnot Serge

Abstract excerpt

Monocytes/macrophages are major effectors of lung inflammation associated with various forms of pulmonary hypertension (PH). Interactions between the CCL2/CCR2 and CX3CL1/CX3CR1 chemokine systems that guide phagocyte infiltration are incompletely understood. Our objective was to explore the individual and combined actions of CCL2/CCR2 and CX3CL1/CX3CR1 in hypoxia-induced PH in mice; particularly their roles in...

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Share to Chemokine CCL2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension, Pulmonary

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Source

Identifiers

PMID: 28125278
DOI: 10.1165/rcmb.2016-0201OC

Genes

CCL2
CCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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