Article
Monocyte subtypes and the CCR2 chemokine receptor in cardiovascular disease.
Clinical science (London, England : 1979) - 1 Jun 2017
França Carolina N, Izar Maria C O, Hortêncio Marinella N S, do Amaral Jônatas B, Ferreira Carlos E S, Tuleta Izabela D, Fonseca Francisco A H
Abstract excerpt
Monocytes circulate in the blood and migrate to inflammatory tissues, but their functions can be either detrimental or beneficial, depending on their phenotypes. In humans, classical monocytes are inflammatory cluster of differentiation (CD)14++CD16-CCR2++ cells originated from the bone marrow or spleen reservoirs and comprise ≥92% of monocytes. Intermediate monocytes (CD14++CD16+CCR2+) are involved in the...
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