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Article

CRTH2 Mediates Profibrotic Macrophage Differentiation and Promotes Lung Fibrosis

19 May 2022

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a particularly deadly form of pulmonary fibrosis of unknown cause. In patients with IPF, high serum and lung concentrations of CHI3L1 (chitinase 3 like 1) can be detected and are associated with poor survival. However, the roles of CHI3L1 in these diseases have not been fully elucidated. We hypothesize that CHI3L1 interacts with CRTH2 (chemoattractant receptor-homologous...

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Share to Chronic Obstructive Pulmonary Disease (COPD) Research
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PMID: 35585756
DOI: 10.1165/rcmb.2021-0504oc

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