Article
M3 Macrophages Stop Division of Tumor Cells In Vitro and Extend Survival of Mice with Ehrlich Ascites Carcinoma.
Medical science monitor basic research - 26 Jan 2017
Kalish Sergey, Lyamina Svetlana, Manukhina Eugenia, Malyshev Yuri, Raetskaya Anastasiya, Malyshev Igor
Abstract excerpt
BACKGROUND M1 macrophages target tumor cells. However, many tumors produce anti-inflammatory cytokines, which reprogram the anti-tumor M1 macrophages into the pro-tumor M2 macrophages. We have hypothesized that the problem of pro-tumor macrophage reprogramming could be solved by using a special M3 switch phenotype. The M3 macrophages, in contrast to the M1 macrophages, should respond to anti-inflammatory...
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