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Article

Mathematical model of tumor-macrophage interactions: Elucidating the tumor-driven macrophage phenotype reprogramming.

Journal of theoretical biology - 21 Jul 2026

Zhang Haifeng, Qu Yipu, Yang Wuyue, Li Chenghang

Abstract excerpt

The interplay between tumor cells and macrophages plays a central regulatory role in cancer progression. In this study, we developed a mathematical model that incorporates tumor cells, M1-type macrophages, M2-type macrophages and an M3-type macrophage population characterized by dual phenotypic features. First, we analyzed the fundamental mathematical properties of the model and derived the conditions under which...

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Identifiers

PMID: 42106056
DOI: 10.1016/j.jtbi.2026.112494

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