Article
Drosophila Vps13 Is Required for Protein Homeostasis in the Brain.
PloS one - 1 Jan 2017
Vonk Jan J, Yeshaw Wondwossen M, Pinto Francesco, Faber Anita I E, Lahaye Liza L, Kanon Bart, van der Zwaag Marianne, Velayos-Baeza Antonio, Freire Raimundo, van IJzendoorn Sven C, Grzeschik Nicola A, Sibon Ody C M
Abstract excerpt
Chorea-Acanthocytosis is a rare, neurodegenerative disorder characterized by progressive loss of locomotor and cognitive function. It is caused by loss of function mutations in the Vacuolar Protein Sorting 13A (VPS13A) gene, which is conserved from yeast to human. The consequences of VPS13A dysfunction in the nervous system are still largely unspecified. In order to study the consequences of VPS13A protein...
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