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Article

Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function.

Cell reports - 24 Jan 2017

Mgbemena Victoria E, Signer Robert A J, Wijayatunge Ranjula, Laxson Travis, Morrison Sean J, Ross Theodora S

Abstract excerpt

BRCA1 is a well-known DNA repair pathway component and a tissue-specific tumor suppressor. However, its role in hematopoiesis is uncertain. Here, we report that a cohort of patients heterozygous for BRCA1 mutations experienced more hematopoietic toxicity from chemotherapy than those with BRCA2 mutations. To test whether this reflects a requirement for BRCA1 in hematopoiesis, we generated mice with Brca1 mutations...

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Source

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Identifiers

PMID: 28122244
DOI: 10.1016/j.celrep.2016.12.075
PMCID: PMC5267932

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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