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Article

Brca1 deficiency causes bone marrow failure and spontaneous hematologic malignancies in mice.

Blood - 21 Jan 2016

Vasanthakumar Aparna, Arnovitz Stephen, Marquez Rafael, Lepore Janet, Rafidi George, Asom Anase, Weatherly Madison, Davis Elizabeth M, Neistadt Barbara, Duszynski Robert, Vardiman James W, Le Beau Michelle M, Godley Lucy A, Churpek Jane E

Abstract excerpt

BRCA1 is critical for maintenance of genomic stability and interacts directly with several proteins that regulate hematopoietic stem cell function and are part of the Fanconi anemia (FA) double-strand break DNA repair pathway. The effects of complete BRCA1 deficiency on bone marrow (BM) function are unknown. To test the hypothesis that Brca1 is essential in hematopoiesis, we developed a conditional mouse model...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26644450
DOI: 10.1182/blood-2015-03-635599
PMCID: PMC4722284

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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