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Article

Elevated levels of DNA methylation at the OPRM1 promoter region in men with opioid use disorder.

The American journal of drug and alcohol abuse - 1 Jan 2018

Ebrahimi Ghasem, Asadikaram Gholamreza, Akbari Hamed, Nematollahi Mohammad Hadi, Abolhassani Moslem, Shahabinejad Gholamabbas, Khodadadnejad Leyla, Hashemi Mohammad

Abstract excerpt

BACKGROUND: The mu-opioid receptor, encoded by mu-opioid receptor gene (OPRM1), has an important role in the development of addiction to opioids. Its aberrant reduction on the cell membrane is responsible, at least in part, for tolerance and physical dependence. OBJECTIVES: The present study was designed to identify the relationship between opium consumption and epigenetic mechanisms involved in opium addiction....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to OPRM1 gene

Share to Genetic Predisposition to Disease

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Share to Promoter Regions, Genetic

Share to Receptors, Opioid, mu

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Source

Identifiers

PMID: 28121474
DOI: 10.1080/00952990.2016.1275659

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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