Chronic opioid use is associated with increased DNA methylation correlating with increased clinical pain

Abstract excerpt

Environmentally caused changes in chromosomes that do not alter the DNA sequence but cause phenotypic changes by altering gene transcription are summarized as epigenetics. A major epigenetic mechanism is methylation or demethylation at CpG-rich DNA islands. DNA methylation triggered by drugs has largely unexplored therapeutic consequences. Here we report increased methylation at a CpG rich island in the OPRM1...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Diet and metabolism studies
• Share to Epigenetics and DNA Methylation
• Share to Pharmacological Effects and Toxicity Studies