Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of short-term prescription opioids on DNA methylation of the OPRM1 promoter

3 Jun 2020

Abstract excerpt

BACKGROUND: A long-term opioid use has been associated with hypermethylation of the opioid receptor mu 1 (OPRM1) promoter. Very little is currently known about the early epigenetic response to therapeutic opioids. Here, we examine whether we can detect DNA methylation changes associated with a few days' use of prescribed opioids. Genome-wide DNA methylation was assayed in a cohort of 33 opioid-naïve participants...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Neuropeptides and Animal Physiology
Share to Pain Management and Opioid Use

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32493461
DOI: 10.1186/s13148-020-00868-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of short-term prescription opioids on DNA methylation of the OPRM1 promoterPMID 32493461Read ↗

Chronic opioid use is associated with increased DNA methylation correlating with increased clinical painSemantic proximity Read ↗

Epigenetic and sex differences in opioid use disorder in chronic pain: A real‐world study linked with OPRM1 DNA methylationSemantic proximity Read ↗

Elevated levels of DNA methylation at the OPRM1 promoter region in men with opioid use disorder.Semantic proximity Read ↗

Epigenetic variation in OPRM1 gene in opioid‐exposed mother‐infant dyadsSemantic proximity Read ↗

Epigenetic Alterations in Prescription Opioid Misuse: New Strategies for Precision Pain ManagementSemantic proximity Read ↗

Sex Differences in Opioid Response Linked to OPRM1 and COMT genes DNA Methylation/Genotypes Changes in Patients with Chronic PainSemantic proximity Read ↗

Opioid Exposure is Associated with Aberrant DNA Methylation of OPRM1 Promoter Region in a Chinese Han Population.Semantic proximity Read ↗

Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1.Semantic proximity Read ↗

Methylation and expression quantitative trait loci rs1799971 in the OPRM1 gene and rs4654327 in the OPRD1 gene are associated with opioid use disorder.Semantic proximity Read ↗

Genetic Associations of Persistent Opioid Use After Surgery Point to OPRM1 but Not Other Opioid-Related Loci as the Main Driver of Opioid Use Disorder.Semantic proximity Read ↗

Epigenetics in the perioperative periodSemantic proximity Read ↗

Epigenetic regulation in opioid induced hyperalgesiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.