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Article

Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer.

The Journal of biological chemistry - 14 Feb 2014

Kahlert Christoph, Melo Sonia A, Protopopov Alexei, Tang Jiabin, Seth Sahil, Koch Moritz, Zhang Jianhua, Weitz Juergen, Chin Lynda, Futreal Andrew, Kalluri Raghu

Abstract excerpt

Exosomes are small vesicles (50-150 nm) of endocytic origin that are released by many different cell types. Exosomes in the tumor microenvironment may play a key role in facilitating cell-cell communication. Exosomes are reported to predominantly contain RNA and proteins. In this study, we investigated whether exosomes from pancreatic cancer cells and serum from patients with pancreatic ductal adenocarcinoma...

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Share to Chromosomes, Human
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Pancreatic Neoplasms

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins p21(ras)

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Source

Open in PubMed Open full text

Identifiers

PMID: 24398677
DOI: 10.1074/jbc.C113.532267
PMCID: PMC3924256

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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