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Article

Mechanism Governing Human Kappa-Opioid Receptor Expression under Desferrioxamine-Induced Hypoxic Mimic Condition in Neuronal NMB Cells.

International journal of molecular sciences - 20 Jan 2017

Babcock Jennifer, Herrera Alberto, Coricor George, Karch Christopher, Liu Alexander H, Rivera-Gines Aida, Ko Jane L

Abstract excerpt

Cellular adaptation to hypoxia is a protective mechanism for neurons and relevant to cancer. Treatment with desferrioxamine (DFO) to induce hypoxia reduced the viability of human neuronal NMB cells. Surviving/attached cells exhibited profound increases of expression of the human kappa-opioid receptor (hKOR) and hypoxia inducible factor-1α (HIF-1α). The functional relationship between hKOR and HIF-1α was...

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Source

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Identifiers

PMID: 28117678
DOI: 10.3390/ijms18010211
PMCID: PMC5297840

Genes

NMB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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