Article
The gene encoding human retinoic acid-receptor-related orphan receptor α is a target for hypoxia-inducible factor 1
9 Nov 2004
Abstract excerpt
Retinoic acid-receptor-related orphan receptor (ROR) alpha is a nuclear receptor involved in many pathophysiological processes such as cerebellar ataxia, inflammation, atherosclerosis and angiogenesis. In the present study we first demonstrate that hypoxia increases the amount of Rora transcripts in a wide panel of cell lines derived from diverse tissues. In addition, we identified a functional promoter sequence...
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