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Article

Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment.

Journal of cellular biochemistry - 1 May 2006

Risbud Makarand V, Guttapalli Asha, Stokes David G, Hawkins David, Danielson Keith G, Schaer Thomas P, Albert Todd J, Shapiro Irving M

Abstract excerpt

Nucleus pulposus (NP) cells of the intervertebral disc reside in an environment that has a limited vascular supply and generate energy through anaerobic glycolysis. The goal of the present study was to examine the expression and regulation of HIF-1alpha, a transcription factor that regulates oxidative metabolism in nucleus pulposus cells. Nucleus pulposus cells were isolated from rat, human, and sheep disc and...

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Identifiers

PMID: 16408279
DOI: 10.1002/jcb.20765

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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