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Article

Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers

2 Sept 2004

Abstract excerpt

BACKGROUND: The expression of NDRG1 gene is induced by nickel, a transition metal sharing similar physical properties to cobalt. Nickel may create hypoxia-like conditions in cells and induce hypoxia-responsive genes, as does cobalt. Therefore NDRG1 is likely to be another gene induced by hypoxia. HIF-1 is a transcription factor which has a major role in the regulation of hypoxia-responsive genes, and thus it...

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PMID: 15341671
DOI: 10.1186/1471-2156-5-27

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