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Article

Hypoxia-induced cell death and changes in hypoxia-inducible factor-1 activity in PC12 cells upon exposure to nerve growth factor.

Brain research. Molecular brain research - 15 Jul 2002

Charlier Nico, Leclere Norbert, Felderhoff Ursula, Heldt Julia, Kietzmann Thomas, Obladen Michael, Gross Johann

Abstract excerpt

The transcription factor hypoxia-inducible factor-1 (HIF-1) strongly contributes to the expression of adaptive genes under hypoxic conditions. In addition, HIF-1 has been implicated in the regulation of delayed neuronal cell death. Suspension-grown and adherent PC12 cells treated with NGF were used as an experimental model for studying the relationship between hypoxia-induced cell death and activation of HIF-1....

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Source

Identifiers

PMID: 12117547
DOI: 10.1016/s0169-328x(02)00198-5

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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