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Article

Culture adaptation of malaria parasites selects for convergent loss-of-function mutants.

Scientific reports - 24 Jan 2017

Claessens Antoine, Affara Muna, Assefa Samuel A, Kwiatkowski Dominic P, Conway David J

Abstract excerpt

Cultured human pathogens may differ significantly from source populations. To investigate the genetic basis of laboratory adaptation in malaria parasites, clinical Plasmodium falciparum isolates were sampled from patients and cultured in vitro for up to three months. Genome sequence analysis was performed on multiple culture time point samples from six monoclonal isolates, and single nucleotide polymorphism (SNP)...

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Source

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Identifiers

PMID: 28117431
DOI: 10.1038/srep41303
PMCID: PMC5259787

Genes

SRPK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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