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Article

Genomic variation during culture adaptation of genetically complex Plasmodium falciparum clinical isolates.

Microbial genomics - 1 May 2023

Claessens Antoine, Stewart Lindsay B, Drury Eleanor, Ahouidi Ambroise D, Amambua-Ngwa Alfred, Diakite Mahamadou, Kwiatkowski Dominic P, Awandare Gordon A, Conway David J

Abstract excerpt

Experimental studies on the biology of malaria parasites have mostly been based on laboratory-adapted lines, but there is limited understanding of how these may differ from parasites in natural infections. Loss-of-function mutants have previously been shown to emerge during culture of some Plasmodium falciparum clinical isolates in analyses focusing on single-genotype infections. The present study included a...

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PMID: 37204422
DOI: 10.1099/mgen.0.001009
PMCID: PMC10272863

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Source receipt: pubmed, retrieved 7 Sept 2026.

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