Intrinsic multiplication rate variation and plasticity of human blood stage malaria parasites.

doi:10.1038/s42003-020-01349-7

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Article

Intrinsic multiplication rate variation and plasticity of human blood stage malaria parasites.

Communications biology - 28 Oct 2020

Stewart Lindsay B, Diaz-Ingelmo Ofelia, Claessens Antoine, Abugri James, Pearson Richard D, Goncalves Sonia, Drury Eleanor, Kwiatkowski Dominic P, Awandare Gordon A, Conway David J

Abstract excerpt

Pathogen multiplication rate is theoretically an important determinant of virulence, although often poorly understood and difficult to measure accurately. We show intrinsic asexual blood stage multiplication rate variation of the major human malaria parasite Plasmodium falciparum to be associated with blood-stage infection intensity in patients. A panel of clinical isolates from a highly endemic West African...

Topics

Cell Proliferation
Gene Expression Regulation
Genome, Protozoan
Ghana
Humans
Malaria, Falciparum
Mutation
Plasmodium falciparum

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Identifiers

PMID: 33116247
DOI: 10.1038/s42003-020-01349-7
PMCID: PMC7595149

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