Article

Adaptation of the yeast gene knockout collection is near-perfectly predicted by fitness and diminishing return epistasis

2022-03-27

Abstract excerpt

<h4>ABSTRACT</h4> Adaptive evolution of clonally dividing cells and microbes is the ultimate cause of cancer and infectious diseases. The possibility of constraining the adaptation of cell populations, by inhibiting proteins that enhance their evolvability has therefore attracted substantial interest. However, our current understanding of how individual genes influence the speed of adaptation is limited, partly b...

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Literature Corpus work: 9b6a4aa7-e139-5af9-83fd-253a874c8aea
DOI: 10.1101/2022.03.25.485769

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