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Article

Adaptation of the yeast gene knockout collection is near-perfectly predicted by fitness and diminishing return epistasis.

G3 (Bethesda, Md.) - 4 Nov 2022

Persson Karl, Stenberg Simon, Tamás Markus J, Warringer Jonas

Abstract excerpt

Adaptive evolution of clonally dividing cells and microbes is the ultimate cause of cancer and infectious diseases. The possibility of constraining the adaptation of cell populations, by inhibiting proteins enhancing the evolvability, has therefore attracted interest. However, our current understanding of how genes influence adaptation kinetics is limited, partly because accurately measuring adaptation for many...

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Share to Adaptation, Physiological
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Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Knockout Techniques

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Share to Saccharomyces cerevisiae

Source

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Identifiers

PMID: 36083011
DOI: 10.1093/g3journal/jkac240
PMCID: PMC9635671

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