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Article

ODC1 restricts meningeal B cell age-associated-like phenotype and function in multiple sclerosis: A human and experimental study.

Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2026

Zurawski Jonathan, Tuncer Alara, Profant Martin R, Wang Jianuo, Green Miranda, Park Yoobhin, Cao Ke, Paris Simon, Tauhid Shahamat, Jalkh Youmna, Quattrucci Molly, Chu Renxin, Cao Xingshan, Kiss Alex, Chitnis Tanuja, Weiner Howard, Clish Clary B, Bakshi Rohit, Wang Chao

Abstract excerpt

Meningeal inflammation, as a clinical feature of multiple sclerosis (MS), is associated with worse clinical disease outcomes. In both relapsing and secondary progressive MS and the experimental autoimmune encephalomyelitis (EAE) MS model, the meninges have been found to contain ectopic lymphoid follicles enriched with B cells. The metabolic requirement of meningeal B cell function in MS or EAE is not well...

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Topics

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Share to B-Lymphocytes
Share to Encephalomyelitis, Autoimmune, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MOG gene

Share to Mice, Inbred C57BL

Share to Multiple Sclerosis

Share to Ornithine Decarboxylase

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Source

Open in PubMed Open full text

Identifiers

PMID: 41824499
DOI: 10.1073/pnas.2526147123
PMCID: PMC12993946

Genes

ODC1
MOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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