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Article

Molecular characterization of CD44+/CD24-/Ck+/CD45- cells in benign and malignant breast lesions.

Virchows Archiv : an international journal of pathology - 1 Mar 2017

Da Cruz Paula Arnaud, Leitão Catarina, Marques Oriana, Rosa Ana Margarida, Santos Ana Helena, Rêma Alexandra, de Fátima Faria Maria, Rocha Ana, Costa José Luís, Lima Margarida, Lopes Carlos

Abstract excerpt

Breast cancer epithelial cells with the CD44+/CD24-/low phenotype possess tumor-initiating cells and epithelial-mesenchymal transition (EMT) capacity. Massive parallel sequencing can be an interesting approach to deepen the molecular characterization of these cells. We characterized CD44+/CD24-/cytokeratin(Ck)+/CD45- cells isolated through flow cytometry from 43 biopsy and 6 mastectomy samples harboring different...

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Identifiers

PMID: 28116522
DOI: 10.1007/s00428-017-2068-4

Genes

AKT1
NOTCH1
PTEN
RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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