Article
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines.
Breast cancer research and treatment - 1 May 2010
Hollestelle Antoinette, Nagel Jord H A, Smid Marcel, Lam Suzanne, Elstrodt Fons, Wasielewski Marijke, Ng Ser Sue, French Pim J, Peeters Justine K, Rozendaal Marieke J, Riaz Muhammad, Koopman Daphne G, Ten Hagen Timo L M, de Leeuw Bertie H C G M, Zwarthoff Ellen C, Teunisse Amina, van der Spek Peter J, Klijn Jan G M, Dinjens Winand N M, Ethier Stephen P, Clevers Hans, Jochemsen Aart G, den Bakker Michael A, Foekens John A, Martens John W M, Schutte Mieke
Abstract excerpt
Breast cancer has for long been recognized as a highly diverse tumor group, but the underlying genetic basis has been elusive. Here, we report an extensive molecular characterization of a collection of 41 human breast cancer cell lines. Protein and gene expression analyses indicated that the collection of breast cancer cell lines has retained most, if not all, molecular characteristics that are typical for...
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