Article
Genomic high-resolution profiling of single CKpos/CD45neg flow-sorting purified circulating tumor cells from patients with metastatic breast cancer.
Clinical chemistry - 1 Oct 2014
Neves Rui P L, Raba Katharina, Schmidt Oliver, Honisch Ellen, Meier-Stiegen Franziska, Behrens Bianca, Möhlendick Birte, Fehm Tanja, Neubauer Hans, Klein Christoph A, Polzer Bernhard, Sproll Christoph, Fischer Johannes C, Niederacher Dieter, Stoecklein Nikolas H
Abstract excerpt
BACKGROUND: Circulating tumor cells (CTCs) are promising surrogate markers for systemic disease, and their molecular characterization might be relevant to guide more individualized cancer therapies. To enable fast and efficient purification of individual CTCs, we developed a work flow from CellSearch(TM) cartridges enabling high-resolution genomic profiling on the single-cell level. METHODS: Single CTCs were...
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