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Feasibility of a workflow for the molecular characterization of single cells by next generation sequencing

1 Sept 2015

Abstract excerpt

The purpose of the study was to explore the feasibility of a protocol for the isolation and molecular characterization of single circulating tumor cells (CTCs) from cancer patients using a single-cell next generation sequencing (NGS) approach. To reach this goal we used as a model an artificial sample obtained by spiking a breast cancer cell line (MDA-MB-231) into the blood of a healthy donor. Tumor cells were...

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PMID: 27077040
DOI: 10.1016/j.bdq.2015.07.002

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