Transcriptional profiles of different states of cancer stem cells in triple-negative breast cancer

Abstract excerpt

Breast cancer stem cells (BCSCs) are thought to be responsible for tumor initiation, metastasis and relapse. Our group and others have described markers useful in isolating BCSCs just as aldehyde dehydrogenase positive (ALDH + ) or CD24 − CD44 + . In fact, cells which simultaneously express both sets of markers have the highest tumor initiating capacity. Although the transcriptomic profile of cells expressing...

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