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Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease

20 Jan 2017

Abstract excerpt

Abstract Brain insulin resistance (IR), which depends on insulin‐receptor‐substrate‐1 (IRS‐1) phosphorylation, is characteristic of Alzheimer's disease (AD). Previously, we demonstrated higher pSer312‐IRS‐1 (ineffective insulin signaling) and lower p‐panTyr‐IRS‐1 (effective insulin signaling) in neural origin‐enriched plasma exosomes of AD patients vs. controls. Here, we hypothesized that these exosomal...

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PMID: 28105773
DOI: 10.1002/hbm.23494

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