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Article

Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 May 2014

Roberts Rosebud O, Knopman David S, Cha Ruth H, Mielke Michelle M, Pankratz V Shane, Boeve Bradley F, Kantarci Kejal, Geda Yonas E, Jack Clifford R, Petersen Ronald C, Lowe Val J

Abstract excerpt

UNLABELLED: Dysfunctional insulin signaling may affect brain metabolism or amyloid deposition. We investigated the associations of type 2 diabetes with amyloid accumulation measured using (11)C-Pittsburgh compound B ((11)C-PiB) and brain hypometabolism measured using (18)F-FDG PET. METHODS: We studied a sample of nondemented participants from the population-based Mayo Clinic Study of Aging. All subjects underwent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24652830
DOI: 10.2967/jnumed.113.132647
PMCID: PMC4011952

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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