Article
iPSC-derived familial Alzheimer's PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling.
Molecular neurodegeneration - 26 Jun 2018
Moreno Cesar L, Della Guardia Lucio, Shnyder Valeria, Ortiz-Virumbrales Maitane, Kruglikov Ilya, Zhang Bin, Schadt Eric E, Tanzi Rudolph E, Noggle Scott, Buettner Christoph, Gandy Sam
Abstract excerpt
BACKGROUND: Type 2 diabetes (T2D) is a recognized risk factor for the development of cognitive impairment (CI) and/or dementia, although the exact nature of the molecular pathology of T2D-associated CI remains obscure. One link between T2D and CI might involve decreased insulin signaling in brain and/or neurons in either animal or postmortem human brains as has been reported as a feature of Alzheimer's disease...
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