Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation of the HERC 1 Ubiquitin Ligase Impairs Associative Learning in the Lateral Amygdala.

Molecular neurobiology - 1 Feb 2018

Pérez-Villegas Eva Mª, Negrete-Díaz José V, Porras-García Mª Elena, Ruiz Rocío, Carrión Angel M, Rodríguez-Moreno Antonio, Armengol José A

Abstract excerpt

Tambaleante (tbl/tbl) is a mutant mouse that carries a spontaneous Gly483Glu substitution in the HERC1 (HECT domain and RCC1 domain) E3 ubiquitin ligase protein (HERC1). The tbl/tbl mutant suffers an ataxic syndrome given the almost complete loss of cerebellar Purkinje cells during adult life. More recent analyses have identified alterations at neuromuscular junctions in these mice, as well as in other neurons of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amygdala
Share to Avoidance Learning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Conditioning, Classical

Share to Dendritic Spines

Share to Long-Term Potentiation

Share to Neurons

Share to Synapses

Share to Ubiquitin-Protein Ligases

Source

Identifiers

PMID: 28102468
DOI: 10.1007/s12035-016-0371-8

Genes

HERC1
RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation of the HERC 1 Ubiquitin Ligase Impairs Associative Learning in the Lateral Amygdala.PMID 28102468Read ↗

The HERC1 ubiquitin ligase regulates presynaptic membrane dynamics of central synapses.Semantic proximity Read ↗

The HERC proteins and the nervous system.Semantic proximity Read ↗

HERC1 Ubiquitin Ligase Is Required for Normal Axonal Myelination in the Peripheral Nervous System.Semantic proximity Read ↗

Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality.Semantic proximity Read ↗

Enhancement of long-term memory retention and short-term synaptic plasticity in cbl-b null mice.Semantic proximity Read ↗

NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity.Semantic proximity Read ↗

Behavioral and neuromorphological characterization of a novel Tuba1 mutant mouse.Semantic proximity Read ↗

Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene.Semantic proximity Read ↗

Mice lacking leukocyte common antigen-related (LAR) protein tyrosine phosphatase domains demonstrate spatial learning impairment in the two-trial water maze and hyperactivity in multiple behavioural tests.Semantic proximity Read ↗

Behavioral characterization of mice lacking the ubiquitin ligase UBR1 of the N-end rule pathway.Semantic proximity Read ↗

Expression of C1ql3 in Discrete Neuronal Populations Controls Efferent Synapse Numbers and Diverse Behaviors.Semantic proximity Read ↗

Spatial memory dissociations in mice lacking GluR1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.