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The HERC proteins and the nervous system.

Seminars in cell & developmental biology - 1 Dec 2022

Pérez-Villegas Eva M, Ruiz Rocío, Bachiller Sara, Ventura Francesc, Armengol Jose A, Rosa Jose Luis

Abstract excerpt

The HERC protein family is one of three subfamilies of Homologous to E6AP C-terminus (HECT) E3 ubiquitin ligases. Six HERC genes have been described in humans, two of which encode Large HERC proteins -HERC1 and HERC2- with molecular weights above 520 kDa that are constitutively expressed in the brain. There is a large body of evidence that mutations in these Large HERC genes produce clinical syndromes in which...

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PMID: 34848147
DOI: 10.1016/j.semcdb.2021.11.017

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