Article
Mice lacking leukocyte common antigen-related (LAR) protein tyrosine phosphatase domains demonstrate spatial learning impairment in the two-trial water maze and hyperactivity in multiple behavioural tests.
Behavioural brain research - 23 Sept 2004
Kolkman Marloes J M, Streijger Femke, Linkels Marianne, Bloemen Marjon, Heeren Dick J, Hendriks Wiljan J A J, Van der Zee Catharina E E M
Abstract excerpt
Leukocyte common antigen-related (LAR) protein is a cell adhesion molecule-like receptor-type protein tyrosine phosphatase. We previously reported that in LAR tyrosine phosphatase-deficient (LAR-Delta P) mice the number and size of basal forebrain cholinergic neurons as well as their innervation of the hippocampal area was reduced. With the hippocampus being implicated in behavioural activity aspects, including...
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