Article
HERC1 Ubiquitin Ligase Is Required for Normal Axonal Myelination in the Peripheral Nervous System.
Molecular neurobiology - 1 Dec 2018
Bachiller Sara, Roca-Ceballos María Angustias, García-Domínguez Irene, Pérez-Villegas Eva María, Martos-Carmona David, Pérez-Castro Miguel Ángel, Real Luis Miguel, Rosa José Luis, Tabares Lucía, Venero José Luis, Armengol José Ángel, Carrión Ángel Manuel, Ruiz Rocío
Abstract excerpt
A missense mutation in HERC1 provokes loss of cerebellar Purkinje cells, tremor, and unstable gait in tambaleante (tbl) mice. Recently, we have shown that before cerebellar degeneration takes place, the tbl mouse suffers from a reduction in the number of vesicles available for release at the neuromuscular junction (NMJ). The aim of the present work was to study to which extent the alteration in HERC1 may affect...
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