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Article

Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality.

Nature neuroscience - 1 Feb 2014

Huang Tzyy-Nan, Chuang Hsiu-Chun, Chou Wen-Hsi, Chen Chiung-Ya, Wang Hsiao-Fang, Chou Shen-Ju, Hsueh Yi-Ping

Abstract excerpt

The neuron-specific transcription factor T-box brain 1 (TBR1) regulates brain development. Disruptive mutations in the TBR1 gene have been repeatedly identified in patients with autism spectrum disorders (ASDs). Here, we show that Tbr1 haploinsufficiency results in defective axonal projections of amygdalar neurons and the impairment of social interaction, ultrasonic vocalization, associative memory and cognitive...

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Source

Identifiers

PMID: 24441682
DOI: 10.1038/nn.3626

Genes

TBR1
FOS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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