Enhancement of long-term memory retention and short-term synaptic plasticity in cbl-b null mice.

doi:10.1073/pnas.0601043103

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Article

Enhancement of long-term memory retention and short-term synaptic plasticity in cbl-b null mice.

Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 2006

Tan Dong Ping, Liu Qi-Ying, Koshiya Naohiro, Gu Hua, Alkon Daniel

Abstract excerpt

The cbl-b gene is a member of the cbl protooncogene family. It encodes a protein with multiple domains, which can interact with other proteins in a variety of signaling pathways. The functions of cbl family genes in the brain are unknown. In this report, we used genetic, immunohistochemical, behavioral, and electrophysiological approaches to study the role of cbl-b in learning and memory. Cbl-b null mice...

Topics

Adaptor Proteins, Signal Transducing
Animals
Brain
Memory
Mice
Mice, Inbred C57BL
Mice, Knockout
Motor Activity
Mutation
Neuronal Plasticity
Proto-Oncogene Proteins c-cbl
Synapses
Time Factors

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Identifiers

PMID: 16549761
DOI: 10.1073/pnas.0601043103
PMCID: PMC1458805

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