Article
Individualised multiplexed circulating tumour DNA assays for monitoring of tumour presence in patients after colorectal cancer surgery.
Scientific reports - 19 Jan 2017
Ng Sarah B, Chua Clarinda, Ng Matthew, Gan Anna, Poon Polly Sy, Teo Melissa, Fu Cherylin, Leow Wei Qiang, Lim Kiat Hon, Chung Alexander, Koo Si-Lin, Choo Su Pin, Ho Danliang, Rozen Steve, Tan Patrick, Wong Mark, Burkholder William F, Tan Iain Beehuat
Abstract excerpt
Circulating tumour DNA (ctDNA) has the potential to be a specific biomarker for the monitoring of tumours in patients with colorectal cancer (CRC). Here, our aim was to develop a personalised surveillance strategy to monitor the clinical course of CRC after surgery. We developed patient-specific ctDNA assays based on multiplexed detection of somatic mutations identified from patient primary tumours, and applied...
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